Argireline from Lipotec S.A. is a new peptide that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development.  It has been shown to inhibit the formation of the snare complex as well as catecholamine release.  These inhibitors confer anti-aging activity on argireline and closely relate to the basic biochemical mechanisms of wrinkle formation.

Facial wrinkling associated with aging is caused and exacerbated by many factors.  Beyond the physical pathways, molecular mechanisms involved in facial aging include changes in collagen formation, elastin polypeptide degradation, and problems with the skin’s lipid matrix.  Recent studies clearly establish that these changes can be significantly reduced by inhibiting “snare” complex formation, a core of membrane proteins that mediate neuronal exocytosis (collagen and elastin twisting of fibers and malformation).  Their inhibition by short synthetic peptides can decrease facial wrinkle formation and the appearance of aging.  The overproduction and release of catecholamines also encourages the formation of wrinkles and fine lines.

Argireline was discovered within Lipotec’s library of hexapeptides and has been proven effective in inhibiting the “snare” complex formation and catecholamine release.  Once identified, it was synthesized by solid phase peptide synthesis, purified and characterized.

See also:  Ultimate Radiance Rejuvenating Serum with Argireline